Objective: Validation of a bedside test to objectify the fixation suppression of the vestibulo-ocular reflex (FS-VOR) in patients with a cerebellar syndrome and healthy controls.
Methods: The vestibulo-ocular reflex and its fixation suppression were assessed by video-nystagmography (VNG) in 20 healthy subjects (mean age 56 ± 15) and 19 patients with a cerebellar syndrome (mean age 70 ± 11). The statistical cutoff delineating normal from pathological FS-VOR was determined at the 2.5th percentile of the normal distribution of the healthy cohort. VNG was then compared to a bedside test, where eye movements were recorded with a smartphone while patients were rotated on a swivel chair at a defined speed and amplitude. These videos were rated as normal or pathological FS-VOR by six blinded raters, and results compared to VNG.
Results: VNG in healthy controls showed FS-VOR with a reduction of nystagmus beats by 95.0% ± 7.2 (mean ± SD). The statistical cutoff was set at 80.6%. Cerebellar patients reduced nystagmus beats by only 26.3% ± 25.1. Inter-rater agreement of the smartphone video ratings was 85%. The sensitivity of the video ratings to detect an impaired FS-VOR was 99%, its specificity 92%. Inter-test agreement was 91%.
Conclusion: The smartphone bedside test is an easily performed, reliable, sensitive, specific, and inexpensive alternative for assessing FS-VOR.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351825 | PMC |
| http://dx.doi.org/10.1007/s00415-020-09947-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Survey on Quality of Services, Training, and Attitude of Dermatology Trainee Residents About Sexually Transmitted Infections in Teaching Hospitals Across India.
Indian Dermatol Online J
December 2024
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Introduction: The incidence of sexually transmitted infections (STIs) has increased disproportionately to STI services. It is uncertain how many residents trained in STI services continue them. This study assessed the self-rated quality of training and attitudes about STI services amongst residents of Indian teaching hospitals.
View Article and Find Full Text PDFCeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water.
J Pharm Anal
October 2024
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
The overuse of antibiotics has led to the severe contamination of water bodies, posing a considerable hazard to human health. Therefore, the development of an accurate and rapid point-of-care testing (POCT) platform for the quantitative detection of antibiotics is necessary. In this study, Cerium oxide (CeO) and Ferrosoferric oxide (FeO) nanoparticles were simultaneously encapsulated into N-doped nanofibrous carbon microspheres to form of a novel nanozyme (CeFe-NCMzyme) with a porous structure, high surface area, and N-doped carbon material properties, leading to a considerable enhancement of the peroxidase (POD)-like activity compared with that of the CeO or FeO nanoparticles alone.
View Article and Find Full Text PDFIntroduction: Fentanyl and xylazine test strips (FTS, XTS) are simple point-of-care tests that determine the presence of fentanyl or xylazine in a substance before use. Access to FTS and XTS is limited. For pharmacists who are willing to sell an FTS, there is little guidance about how to implement FTS sales and counseling as no training for community pharmacists regarding FTS and XTS exists.
View Article and Find Full Text PDFUsing a Serious Game to Teach Central Line Care in Pediatric Critical Care Nursing.
Am J Nurs
February 2025
Mouhammad Yabrodi, Kamal Abulebda, and Riad Lutfi are associate professors and physicians at the Indiana University School of Medicine and Riley Hospital for Children, IU Health, Indianapolis, IN, where Mara E. Nitu is a professor and chief medical officer and Colin M. Rogerson is an assistant professor and physician. Kellie J. Pearson is a critical care respiratory therapist at IU Health, Indianapolis, IN, and Tracy Spitzer is a clinical nurse specialist at Riley Hospital for Children, IU Health, Indianapolis, IN. Nathanael Thomas Tavares is chief executive officer at Flyover Zone, Indianapolis, IN. Contact author: Mouhammad Yabrodi, The authors have disclosed no potential conflicts of interest, financial or otherwise.
Background: Central venous catheters (CVCs) are used in pediatric patients to deliver IV fluids, blood products, medications, and nutrients. Potential complications include central line infection, which carries a high risk of morbidity and mortality in this population. Pediatric critical care nurses play a crucial role in helping to reduce the risk of infection.
View Article and Find Full Text PDFInterpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context.
Anesth Analg
January 2025
From the Department of Anesthesiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Background: Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigates the inter- and intrarater reliability of ROTEM interpretation among experts and compares their interpretations with a ROTEM-guided algorithm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!