AI Article Synopsis
- The text proposes that the excessive blood clotting and immune reactions commonly observed in COVID-19 patients may be worsened by a lack of a certain regulator.
- This regulator is identified as protein S, which plays a dual role in the body: it helps prevent excessive clotting and also activates certain receptors that suppress the immune response.
- The depletion of protein S could be a key factor contributing to the severe symptoms seen in COVID-19 patients.
Article Abstract
We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor tyrosine kinases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264968 | PMC |
| http://dx.doi.org/10.1038/s41577-020-0354-x | DOI Listing |
Publication Analysis
Top Keywords
blood clots
4
clots tam
4
tam receptor
4
receptor signalling
4
signalling covid-19
4
covid-19 pathogenesis
4
pathogenesis exuberant
4
exuberant blood
4
blood clotting
4
clotting immune
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!