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A data management system for precision medicine.
PLOS Digit Health
January 2025
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands.
Precision, or personalised medicine has advanced requirements for medical data management systems (MedDMSs). MedDMS for precision medicine should be able to process hundreds of parameters from multiple sites, be adaptable while remaining in sync at multiple locations, real-time syncing to analytics and be compliant with international privacy legislation. This paper describes the LogiqSuite software solution, aimed to support a precision medicine solution at the patient care (LogiqCare), research (LogiqScience) and data science (LogiqAnalytics) level.
View Article and Find Full Text PDFEthical Use of Cadaveric Images in Anatomical Textbooks, Atlases, and Journals: A Consensus Response From Authors and Editors.
Clin Anat
January 2025
Department of Neurosurgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Nowadays, consent to use donor bodies for medical education and research is obtained from the body donors and their families before the donation. Recently, the International Federation of Associations of Anatomists (IFAA) published guidelines that could restrict the appearance of cadaveric images in commercial anatomical resources such as textbooks and other educational products. These guidelines state that the donor must expressly consent to using such images for this purpose.
View Article and Find Full Text PDFInfectious keratoconjunctivitis in European bison (Bison bonasus) in Poland: risk factors, epidemiology and anatomopathological changes with analysis of potential role of Thelazia nematodes in the disease development.
BMC Vet Res
November 2024
Department of Food Hygiene and Public Health Protection, Institute of Veterinary Medicine, Warsaw University of Life Sciences-WULS, Nowoursynowska 159, 02-776, Warsaw, Poland.
Background: Infectious keratoconjunctivitis (IKC) is a common ocular disease of ruminants worldwide. Recently, an outbreak of infectious keratoconjunctivitis was observed in the European bison in Poland. Hundreds of animals show conjunctival congestion, corneal opacity, and ulceration, leading to total blindness.
View Article and Find Full Text PDFMatrix-assisted laser desorption/ionization mass spectrometry imaging as a new tool for molecular histopathology in epilepsy surgery.
Epilepsia
December 2024
Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Article Synopsis
- The study investigates the use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to improve the diagnosis of focal cortical dysplasia (FCD) in epilepsy patients who haven't responded to medication.
- MALDI-MSI was applied to brain tissue samples from 10 FCD type IIb cases, revealing unique histopathological traits and allowing visualization of diagnostic markers directly within the tissue.
- This research aims to create a molecular signature library to better distinguish between tissue characteristics, potentially enhancing patient classification and outcomes after epilepsy surgery.
Advanced nanoparticles in osteoarthritis treatment.
Biomater Transl
June 2024
Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Osteoarthritis (OA) is the most prevalent degenerative joint disorder, affecting hundreds of millions of people globally. Current clinical approaches are confined to providing only symptomatic relief. Research over the past two decades has established that OA is not merely a process of wear and tear of the articular cartilage but involves abnormal remodelling of all joint tissues.
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