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Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells Is Associated With Tumor Relapse in Head and Neck Squamous Cell Carcinoma. | LitMetric
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Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells Is Associated With Tumor Relapse in Head and Neck Squamous Cell Carcinoma.

Hiroe Tada Hideyuki Takahashi Shota Ida Yurino Nagata Kazuaki Chikamatsu

Anticancer Res

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan

Published: June 2020

AI Article Synopsis

  • - The study investigates how the characteristics of circulating tumor cells (CTCs) in patients with head and neck squamous cell carcinoma (HNSCC) relate to cancer progression and response to treatment.
  • - Researchers classified CTCs from 44 patients with non-recurrent and 42 with recurrent/metastatic HNSCC based on specific markers indicating epithelial-mesenchymal transition (EMT) status, finding important links to clinical outcomes.
  • - Results show that an epithelial (EM) CTC phenotype is more common in patients without disease recurrence and those achieving a complete response, while a mesenchymal phenotype predominates in recurrent/metastatic cases, suggesting CTCs have distinct roles in cancer progression.

Article Abstract

Background/aim: We aimed to elucidate the clinical implication of the epithelial-mesenchymal plasticity of circulating tumor cells (CTCs) in patients with head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: CTCs isolated from 44 patients with non-recurrent/metastatic HNSCC and 42 with recurrent/metastatic (R/M) HNSCC were classified into four epithelial-mesenchymal transition (EMT) statuses based on the expression of epithelial (keratin 19) and mesenchymal (vimentin) markers and the relationships between EMT status in CTCs and clinical factors were investigated.

Results: EM CTC phenotype was more frequent in patients without recurrence/metastasis (p=0.0468) and was also more frequent in those with a complete response (p=0.0346). The EM phenotype constituted the major proportion of the CTCs detected in patients with R/M HNSCC (p=0.0374).

Conclusion: CTCs may play unique roles at various stages of metastasis through transitioning from epithelial to mesenchymal phenotypes.

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 Source
http://dx.doi.org/10.21873/anticanres.14345DOI Listing

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