Introduction: Tadalafil improves lower urinary tract symptoms (LUTS) including nocturia. However, the effect of tadalafil on the nocturia-related quality of life (QoL) is still unknown.
Objective: The effects of tadalafil on nocturia and nocturia-related QoL were evaluated prospectively in patients with benign prostatic hyperplasia (BPH) as a multicenter study.
Methods: Eligible men were ≥40 years with nocturia ≥2 and a prostate volume ≥20 mL. Patients were asked to complete a self-report questionnaire on the International Prostate Symptom Score (IPSS), the Nocturia Quality of Life questionnaire (N-QoL) and the International Index of Erectile Function 5 (IIEF5). Urinary frequency volume charts (FVCs) were also evaluated. These measures were evaluated at baseline, and after 4, 8, and 12 weeks of tadalafil administration (5 mg once daily).
Results: Thirty-one patients with a mean age of 74 years, a mean prostate volume of 31 mL, and a mean prostate-specific antigen level of 2.8 ng/mL were included. Treatment with tadalafil significantly improved their nocturia after 4 weeks, and these improvements were maintained for the 12-week treatment period. Total N-QoL score in new patients and several N-QoL items (inadequate sleep at night and overall bother) in all patients improved significantly after tadalafil treatment. FVCs revealed a significant improvement in the number of hours of undisturbed sleep (HUS) after treatment with tadalafil. No serious adverse events were observed.
Conclusions: This study indicates that tadalafil 5 mg once daily improves nocturia, nocturia-related QoL, and HUS in BPH patients with nocturia. These results suggest that tadalafil can offer a clinically meaningful treatment option for BPH patients with nocturia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000506489 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Overactive Bladder and Dry Mouth on Subjective and Comprehensive Sleep Quality in Older Adults With Nocturia.
Neurourol Urodyn
November 2024
Department of Urology, Nara Medical University, Kashihara, Japan.
Background: Nocturia is among the most common and bothersome urinary tract symptoms in older adults. While sleep quality is key to nocturia management, there is little information on the impact of nocturia itself on sleep quality. We investigated the impacts of nocturia on sleep quality and quality of life and explored factors contributing to reduced sleep quality.
View Article and Find Full Text PDFRetrospective Evaluation of the Efficacy of Electrophysiological Appropriate Techniques for Nocturia Following Radical Prostatectomy.
Am J Mens Health
October 2024
Department of Urology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China.
This study retrospectively examines the effectiveness of low-frequency electrical stimulation for addressing nocturia in patients experiencing urinary incontinence after undergoing radical prostatectomy. We reviewed the outcomes of 32 patients who had undergone radical prostatectomy and subsequently experienced urinary incontinence. These patients were divided into the control group ( = 16) who received pelvic floor muscle training and the treatment group ( = 16) who underwent electrophysiological appropriate technique treatment in conjunction with pelvic floor muscle training.
View Article and Find Full Text PDFEffect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study.
Asian J Urol
July 2024
Department of Otolaryngology, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan, China.
Objective: Obstructive sleep apnea (OSA) is one of the etiologies of nocturia. We analyzed polysomnography (PSG) results to determine correlated factors related to nocturia in OSA patients with different severity.
Methods: Patients with suspected OSA were examined using PSG.
Factors related to nocturia-specific quality of life in renal transplantation patients.
Low Urin Tract Symptoms
May 2024
Department of Urology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Article Synopsis
- The study examines how renal transplantation (RTX) affects the quality of life (QOL) related to nocturia, which may worsen due to conditions like polyuria and decreased bladder capacity.
- Researchers analyzed 59 RTX patients using nocturia-specific QOL questionnaires, finding that increased nocturia frequency, aging, and a longer time post-transplant negatively impacted various QOL scores.
- The findings highlight the need for holistic care strategies for RTX patients to enhance their nocturia-specific quality of life, considering factors such as aging and time since the transplant.
Bipolar radiofrequency thermotherapy vs. transurethral resection of the prostate: Effect on nocturia as a result of benign prostatic obstruction.
Can Urol Assoc J
November 2022
Department of Urology, Lokman Hekim University, Ankara, Turkey.
Introduction: The purpose of this study was to investigate and compare the effects of radiofrequency thermotherapy (RF) thermotherapy and transurethral resection of the prostate (TURP) on nocturia and associated quality of life in patients diagnosed with benign prostatic obstruction (BPO) under medical treatment who have complaints of persistent nocturia.
Methods: The results of patients who underwent RF thermotherapy and TURP procedures between February 2019 and February 2022 were examined, and their three-month results were compared based on their uroflowmetry values, International Prostate Symptom Score (IPSS) values, nocturia frequency, and Nocturia Quality of Life Questionnaire scores.
Results: While the frequency of nocturia in the RF thermotherapy group that was 4.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!