Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promising, but these often fall short of functional restoration due in part to our incomplete understanding of how these damaged circuits initially developed. Despite these limitations, such strategies provide hope that harnessing developmental mechanisms can restore nervous system functions following damage or disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668600 | PMC |
| http://dx.doi.org/10.1016/j.gde.2020.04.006 | DOI Listing |
Publication Analysis
Top Keywords
nervous system
12
developmental mechanisms
8
repurposing developmental
4
mechanisms adult
4
adult nervous
4
system molecules
4
molecules cellular
4
cellular processes
4
processes nervous
4
system development
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!