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The Henderson-Hasselbalch equation describes the relationship between pH, p (the negative logarithm of the ionization constant), and the ionization of local anesthetics.
Traditional methods to understand this relationship are complicated, as they require converting pH based on each local anesthetic's specific p value.
The proposed graphical solution simplifies the process by plotting p on one axis and the percentage of unionized anesthetic on another, allowing for quick estimation of ionization levels for known local anesthetics.
Article Abstract
The relationship between pH, p, and degree of local anesthetic ionization is quantified by the Henderson-Hasselbalch equation. As presented in standard textbooks, the effect of pH on the degree of ionization of any particular local anesthetic is not immediately clear due to the -axis displaying pH - p, which requires conversion to pH, based on the p for each local anesthetic, a complex process. We present a graphical solution that clarifies the interrelationships between pH, p, and degree of ionization by plotting p on the -axis versus the percentage of unionized local anesthetic on the -axis. The vertical intercept from the -axis to the pH curves allows rapid and accurate estimation of the degree of ionization of any local anesthetic of known p.
