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Genetically driven CD39 expression shapes human tumor-infiltrating CD8 T-cell functions. | LitMetric

AI Article Synopsis

Article Abstract

In our study, we investigated the role of CD39 on tumor-infiltrating CD8 T lymphocytes (CD8 TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent observations correlating the CD39 expression with T-cell exhaustion, we demonstrated a divergent functional activity in CD39 CD8 TILs. On the one hand, CD39 CD8 TILs (as compared to their CD39 counterparts) produced significantly lower IFN-γ and IL-2 amounts, expressed higher PD-1, and inversely correlated with perforin and granzyme B expression. On the other, they displayed a significantly higher proliferative capacity ex vivo that was inversely correlated with the PD-1 expression. Therefore, CD39 CD8 TILs, including those co-expressing the CD103 (a marker of T resident memory [TRM] cells), were defined as partially dysfunctional T cells that correlate with tumor patients with initial progression stages. Interestingly, our results identified for the first time a single nucleotide polymorphism (SNP rs10748643 A>G), as a genetic factor associated with CD39 expression in CD8 TILs. Finally, we demonstrated that compounds inhibiting CD39-related ATPases improved CD39 CD8 T-cell effector function ex vivo, and that CD39 CD8 TILs displayed effective suppression function in vitro. Overall these data suggest that the SNP analysis may represent a suitable predictor of CD39 CD8 T-cell expression in cancer patients, and propose the modulation of CD39 as a new strategy to restore partially exhausted CD8 TILs.

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Source
http://dx.doi.org/10.1002/ijc.33131DOI Listing

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