AI Article Synopsis
- - The study aimed to compare the ovarian response of women with FMR1 premutations versus those with full mutations during preimplantation genetic testing (PGT) for Fragile X syndrome, particularly focusing on potential lower responses in premutated women due to premature ovarian failure.
- - After analyzing 86 IVF/PGT-M cycles from 18 premutated and 12 fully mutated patients, results showed that while premutated women had lower AMH levels and required higher doses of FSH, the number of oocytes and embryos produced were similar between the two groups.
- - Ultimately, the research indicated that despite having lower ovarian reserve, FMR1 premutated patients displayed comparable ovarian responses to fully mutated patients in PGT
Article Abstract
Purpose: To assess if the ovarian response of FMR1 premutated women undergoing preimplantation genetic testing (PGT) for Fragile X syndrome is lower compared with fully mutated patients, due to their frequent premature ovarian failure.
Methods: In a retrospective cohort study from January 2009 to March 2019, we compared PGT outcomes in 18 FMR1 premutated women and 12 fully mutated women and aimed to identify predictive factors of stimulation outcomes.
Results: Eighty-six IVF/PGT-M cycles for FMR1 PGT were analyzed. Premutation and full mutation patients were comparable in terms of age, body mass index (BMI), basal FSH, antral follicular count, and cycle length. However, premutation carriers had significantly lower AMH (1.9 versus 4.0 ng/mL, p = 0.0167). Premutated patients required higher doses of FSH (2740 versus 1944 IU, p = 0.0069) but had similar numbers of metaphase II oocytes (7.1 versus 6.6, p = 0.871) and embryos (5.6 versus 4.9, p = 0. 554). Pregnancy rates (37.1% versus 13.3%, p = 0.1076) were not statistically different in both groups.
Conclusion: In spite of lower ovarian reserve and thanks to an increased total dose of FSH, FMR1 premutated selected patients seem to have similar ovarian response as fully mutated patients. Neither the number of CGG repeats in FMR1 gene nor FMR1 mutation status was good predictors of the number of retrieved oocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376994 | PMC |
| http://dx.doi.org/10.1007/s10815-020-01809-3 | DOI Listing |
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