AI Article Synopsis
- The study investigates the potential of four proteins (LRG1, HMGB1, MMP3, and ANXA1) as biomarkers for ulcerative colitis (UC) inflammation.
- Blood and biopsy samples were collected from UC patients and healthy controls, with levels of these proteins measured alongside endoscopic activity scores.
- Results indicated that ANXA1 and MMP3 levels were significantly lower in healthy controls compared to UC patients, suggesting that ANXA1 could serve as a diagnostic biomarker, while MMP3 may reflect both endoscopic and histological activity in UC.
Article Abstract
Objective: The LRG, HMGB1, MMP3 and ANXA1 proteins have been implicated in different inflammatory pathways in ulcerative colitis (UC), but their role as specific biomarkers of both endoscopic and histological activity has yet to be elucidated. In the present study, we aimed to evaluate the LRG1, HMGB1, MMP3 and ANXA1 as potential serum biomarkers for UC endoscopic and histological activity.
Methods: This cross-sectional study included UC patients under 5-ASA, and healthy controls (HC) undergoing colonoscopy. Blood and biopsy samples were obtained and endoscopic Mayo sub-score (Ms) was recorded for the UC patients. Intramucosal calprotectin as a marker of histologic activity was evaluated in all biopsy samples and serum LRG1, HMGB1, MMP3 and ANXA1 levels were measured in the blood samples.
Results: The HCs ANXA1 level was lower compared to that of the UC group [P = 0.00, area under the curve (AUC) = 0.881] and so was the HCs MMP3 level compared to that of patients (P = 0.00, AUC = 0.835). The HCs ANXA1 levels were also lower compared to these of the independent Ms groups, even to the Ms = 0 (P = 0.00, AUC = 0.913). UC endoscopic activity was associated with MMP3 levels (r = 0.54, P = 0.000) but not with ANXA1, LRG1 and HMGB1 levels CONCLUSION: Serum ANXA1 is a potential diagnostic biomarker of UC and serum MMP3 is a potential biomarker of UC endoscopic and histological activity.
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| http://dx.doi.org/10.1097/MEG.0000000000001783 | DOI Listing |
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