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Wound healing potential of mouth gel containing isopimarane diterpene from rhizomes for treatment of oral stomatitis.
PeerJ
December 2024
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Background: Oral ulcers have an impact on 25% of the global population including patients who are suffering from chemotherapy and radiotherapy treatments. L. has been traditionally used for treatment of mouth sores and tongue blisters.
View Article and Find Full Text PDFMyristica fragrans water extract modulates multiple biological processes to pre-protect anhydrous ethanol-induced gastric ulcers via Akt/JNK/Nrf2 pathway activation.
J Ethnopharmacol
December 2024
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, PR China; Key Laboratory of new drug discovery based on Classic Chinese medicine prescription, Chinese Academy of Medical Sciences; NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance. Electronic address:
Ethnopharmacological Relevance: Myristica fragrans (Nutmeg) is a commonly used Chinese herbal medicine and edible spice. According to Pharmacopoeia of People's Republic of China, it has the effects of warming the middle and promoting qi, astringent intestines, and antidiarrheal. In the record of Compendium of Materia Medica, it is the myristica fragrans water extract (MFWE) that is utilized for therapeutic purposes of gastrointestinal disorders frequently.
View Article and Find Full Text PDFProtective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.
Toxicol Res (Camb)
December 2024
Department of Anatomy and Embryology, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha, Egypt.
Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.
View Article and Find Full Text PDFCorneal protein repair after amniotic membrane photo-tissue bonding versus amniotic membrane graft in the treatment of corneal ulcer (an experimental study).
Sci Rep
December 2024
Department of Medical Application of Laser, Ophthalmic Unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.
Corneal alkali burns persist as a significant challenge in our field, often leading to a prolonged treatment course with various sight-threatening problems. This work, of utmost importance, aimed to apply the photo-tissue bonding technique (PTB) to weld the amniotic membrane (AM) to the corneal surface versus an amniotic membrane graft (AMG) and explore its safety in saving corneal protein against alkali burn.Methods Twenty-seven rabbits with an induced corneal ulcer using 1 mol/L NaOH solution.
View Article and Find Full Text PDFRole of probiotic extracellular vesicles in inter-kingdom communication and current technical limitations in advancing their therapeutic utility.
Extracell Vesicles Circ Nucl Acids
September 2024
Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Melbourne 3086, Victoria, Australia.
Diverse functions of probiotic extracellular vesicles (EVs) have been extensively studied over the past decade, proposing their role in inter-kingdom communication. Studies have explored their therapeutic role in pathophysiological processes ranging from cancer, immunoregulation, and ulcerative colitis to stress-induced depression. These studies have highlighted the significant and novel potential of probiotic EVs for therapeutic applications, offering immense promise in addressing several unmet clinical needs.
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