Small Molecules Restore Telomeres in Patient Stem Cells.

Trends Pharmacol Sci

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Published: August 2020

Genetic defects in telomere maintenance result in stem cell exhaustion and a spectrum of telomere biology diseases. Systemic treatments beyond organ transplantation are lacking for these diseases. Nagpal and colleagues identified small molecules that restore telomere maintenance in patient-derived stem cells, offering a promising therapy for telomere biology diseases.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384241PMC
http://dx.doi.org/10.1016/j.tips.2020.05.003DOI Listing

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