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Drug Development.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: Blood pressure (BP) management is an accessible therapeutic target for dementia prevention. BP variability (BPV) is a newer aspect of BP control recently associated with cognitive decline, dementia and Alzheimer's disease (AD), independent of traditionally targeted mean BP levels. Most of this work has relied on largely non-Hispanic White study samples in observational cohorts.
View Article and Find Full Text PDFBackground: OLX-07010 is an oral small molecule inhibitor of tau self-association that prevented the accumulation of tau aggregates in the htau mouse model expressing wild type human CNS tau isoforms and in P301L tau JNPL3 mice using chronic treatment by administration in diet (Davidowitz et al., 2020, PMID: 31771053; 2023 PMID:37556474). A therapeutic study of JNPL3 mice with chronic treatment from 7-12 months of age inhibited the progression of tau aggregation and improved motor coordination.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Centre for Research in Aging - Donald Berman Maimonides Geriatric Centre, Montreal, QC, Canada.
Background: Screening for elder abuse can cause victims to experience feelings of unpleasantness and/or relive painful memories which can be an ethical concern. Ensuring the safety of all participants/users, in our case long-term care (LTC) residents, is of the utmost importance.
Method: Drawing from approaches used in the intimate partner violence and clinical trials literature, we developed a novel typology of harm and a series of procedures to evaluate any negative consequences that might be incurred as a result of participating in the Piloting the Elder Abuse Suspicion Index-long term care: A Mixed Methods Feasibility Study.
Dementia Care Practice.
Alzheimers Dement
December 2024
Alzheimer Society of Ontario, Toronto, ON, Canada.
Dementia Dialogue is a podcast produced by the Alzheimer Society of Ontario that provides people with lived experience (people living with dementia and care partners) a way to share their stories with each other and the broader community. Listeners who have dementia and care partners gain insight and strengthen their adaptive skills. Listeners who work with people living with dementia and care partners as well as community members at large, develop an understanding of what it means to live with dementia and how these individuals can be supported, thereby increasing awareness about the experience of dementia and decreasing stigma.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
University of Florida, Gainesville, FL, USA.
Introduction: Colonoscopies are medical procedures used to identify colon abnormalities and remove polyps to decrease the incidence of colorectal cancer. Prior to this exam, patients must undergo bowel preparation to ensure proper cleansing of the colon and maximize outcomes (e.g.
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