Aims: The increase in the usage of copper nanoparticles (Cu NPs) in the industrial and medical fields has raised concerns about their possible adverse effects. The present study aims to investigate the potential adverse effects of Cu NPs on the brain of adult male Wistar rats through the estimation of some oxidative stress parameters and acetylcholinesterase (AChE) activity.
Basic Procedures: Cu NPs were prepared and characterized using different techniques: Dynamic Light Scattering, X-Ray Diffraction, Transmission and Scanning Electron Microscopy, Fourier transform Infrared Spectroscopy, in addition to Energy Dispersive X-ray Spectroscopy. Rats were divided into two groups: Cu NPs-treated group (IV injected with 15 mg/kg ˷ 13 nm Cu NPs for 2 successive days) and a control group (injected with saline). Rats of the 2 groups were decapitated simultaneously after 48 h of the last injection. The Cu content in different brain areas was analyzed using inductively coupled plasma mass spectrometry. Moreover, the effect of Cu NPs on brain edema was evaluated. The behavior of rats in an open-field was also examined 24 h post the last injection.
Main Findings: Significant increases of Cu content in the cortex, cerebellum, striatum, thalamus and hippocampus were found. Moreover, Cu NPs lead to the induction of oxidative stress condition in the thalamus, hypothamaus and medulla. In addition, Cu NPs induced significant increases in AChE activity in the medulla, hippocampus, striatum besides midbrain. Cu NPs-injected rats showed also decreased exploratory behaviour.
Principal Conclusion: The results obtained in the present study point to the importance of toxicity assessments in evaluating the efficiency of Cu NPs for the safe implementation in different applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtemb.2020.126505 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects.
ACS Biomater Sci Eng
March 2025
College of Stomatology, Chongqing Medical University, 426 Songshibei Road, Yubei District, Chongqing 401147, China.
Infected bone defects show a significant reduction in neovascularization during the healing process, primarily due to persistent bacterial infection and immune microenvironmental disorders. Existing treatments are difficult to simultaneously meet the requirements of antibacterial and anti-inflammatory treatments for infected bone defects, which is a key clinical therapeutic challenge that needs to be addressed. In this study, a conductive hydrogel based on copper nanoparticles was developed for controlling bacterial infection and remodeling the immune microenvironment.
View Article and Find Full Text PDFMetal Nanoparticles Obtained by Green Hydrothermal and Solvothermal Synthesis: Characterization, Biopolymer Incorporation, and Antifungal Evaluation Against .
Nanomaterials (Basel)
February 2025
N@NO-CEA Group, Center for Environmental Studies, Department of Applied Chemistry and Production Systems, Faculty of Chemical Sciences, University of Cuenca, Cuenca 010203, Ecuador.
Nanoparticles (NPs) have generated significant interest in various fields due to the unique properties that materials exhibit at the nanoscale. This study presents a comparative analysis of copper nanoparticles (Cu-NPs) and cobalt nanoparticles (Co-NPs) synthesized via conventional solvothermal and green hydrothermal synthesis using ethylene glycol and extract, respectively. The conventional solvothermal synthesis showed higher efficiency for both Cu-NPs and Co-NPs with yields of 32.
View Article and Find Full Text PDFSelective Carbon Dioxide Hydrogenation to Olefin-Rich Hydrocarbons by Cu/FeOx Nanoarchitectures Under Atmospheric Pressure.
Nanomaterials (Basel)
February 2025
Department of Nanocatalysis, J. Heyrovský Institute of Physical Chemistry, Dolejškova 2155/3, 18223 Prague 8, Czech Republic.
The conversion of carbon dioxide into fuels and fine chemicals is a highly desirable route for mitigating flue gas emissions. However, achieving selectivity toward olefins remains challenging and typically requires high temperatures and pressures. Herein, we address this challenge using 12 nm copper nanoparticles supported on FeOx micro-rods, which promote the selective hydrogenation of CO to light olefins (C-C) under atmospheric pressure.
View Article and Find Full Text PDFCharacterization and machine learning analysis of hybrid alumina-copper oxide nanoparticles in therminol 55 for medium temperature heat transfer fluid.
Sci Rep
March 2025
Institute of Fluid Dynamics and Thermodynamics, Faculty of Mechanical Engineering, Czech Technical University in Prague, Technická 4, Prague, 166 07, Czech Republic.
Efficient heat dissipation is crucial for various industrial and technological applications, ensuring system reliability and performance. Advanced thermal management systems rely on materials with superior thermal conductivity and stability for effective heat transfer. This study investigates the thermal conductivity, viscosity, and stability of hybrid AlO-CuO nanoparticles dispersed in Therminol 55, a medium-temperature heat transfer fluid.
View Article and Find Full Text PDFA new nanosilver surface plasmon resonance Rayleigh scattering method for determination of trace tert-butylhydroquinone with CuMOF surface molecularly imprinted polyethyleneimine nanocatalytic probe.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin 541004, China; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin 541004, China; Guangxi Key Laboratory of Environmental Processes and Remediation in Ecologically Fragile Regions, China. Electronic address:
A new difunctional recognition and nanocatalytic probe of copper metal-organic framework surface molecularly imprinted polyethyleneimine (CuMOF@MIP) was prepared by microwave procedure, using tert-butylhydroquinone (TBHQ) as the template molecule, CuMOF as the nanosubstrate and polyethyleneimine (PEI) as the functional monomer. The experimental results demonstrate that the CuMOF@MIP nanoprobes exhibit strong catalysis of acrylic acid reduction of silver nitrate to produce silver nanoparticles (AgNP) with surface plasmon resonance Rayleigh scattering (RRS) effect at 330 nm. The new nanocatalytic amplification indicator reaction was studied by RRS and coupled with the recognition function to develop a catalytic analysis strategy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!