AI Article Synopsis
- The Au-Ag nanoparticles coated with polydopamine (Au-Ag-PDA) show high efficiency in converting infrared laser light to heat, making them useful for photothermal therapy.
- When encapsulated in stem cell membranes (Au-Ag-PDA@STCM), these nanoparticles display reduced cytotoxicity, enhancing their therapeutic potential.
- Experiments on sebaceous gland cells (SZ95) and golden hamsters indicate that Au-Ag-PDA@STCM significantly inhibit cell growth and reduce sebaceous gland size and sebum production, suggesting a possible treatment for acne.
Article Abstract
The polydopamine coating on Au-Ag nanoparticles (Au-Ag-PDA) possess excellent photothermal conversion efficiency after absorbing near-infrared laser light. After the stem cell membrane (STCM) encapsulates Au-Ag-PDA (Au-Ag-PDA@STCM), the nanoparticles (NPs) exhibit less cytotoxicity, and further optimizing their efficiency in photothermal therapy. The photothermal activity of Au-Ag-PDA@STCM has not yet been reported. Therefore, in this study, the sebaceous gland cell line SZ95 and the golden hamsters were used to observe the photothermal effects of the Au-Ag-PDA@STCM. SZ95 cells were treated with various concen-trations of Au-Ag-PDA@STCM NPs. The photothermal effect on cell proliferation was analyzed after irradiating the cells with a 808 nm laser. After laser treatment of golden hamsters, the flank organs were observed at 4 different time points. Histological analysis was performed to observe tissue damage. The results suggest that Au-Ag-PDA@STCM NPs significantly inhibited the proliferation of sebaceous gland cells in vitro, and reduced the size of sebaceous glands and sebum secretion in vivo. Therefore, NPs can be used to treat acne by thermally injuring sebaceous gland cells.
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| http://dx.doi.org/10.1016/j.colsurfb.2020.111145 | DOI Listing |
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