In order to overcome the shortcomings of crash data a number of surrogate measures of safety have been developed and proposed by various researchers. One of the most widely used temporal indicators is time-to-collision (TTC) which requires the road users to be on a collision course. Road users that are strictly speaking not on a collision course actually might behave and take evasive actions as if they were, thus indicating that such near-miss situations might also be relevant for safety analysis. Taking that into account, a more flexible indicator T, which does not require the two vehicles to be on a collision course, describes the expected time for the second road user to arrive at the conflict point. Recently extreme value theory (EVT) offering two approaches, block maxima (BM) and Peak over Threshold (POT), has been applied in combination with surrogate indicators to estimate crash probabilities. Most of this research has focused on testing BM and POT as well as validating various surrogate safety indicators by comparing model estimates to actual crash frequencies. The comparison of collision course indicators with indicators including crossing course interactions and their performance using EVT has not been investigated yet. In this study we are seeking answers to under what conditions these indicators perform better and whether they are transferable. Using data gathered at a signalized intersection focusing on left-turning and straight moving vehicle interactions our analysis concluded that the two indicators are transferable with stricter threshold values for T and that POT gives more reasonable results.
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Eur Arch Otorhinolaryngol
January 2025
Vrije Universiteit Brussel, Brussels Health Centre, Brussels, Belgium.
Purpose: Cochlear implants (CI) are the most successful bioprosthesis in medicine probably due to the tonotopic anatomy of the auditory pathway and of course the brain plasticity. Correct placement of the CI arrays, respecting the inner ear anatomy are therefore important. The ideal trajectory to insert a cochlear implant array is defined by an entrance through the round window membrane and continues as long as possible parallel to the basal turn of the cochlea.
View Article and Find Full Text PDFNat Chem
January 2025
Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
Amyloid fibrils are highly stable misfolded protein assemblies that play an important role in several neurodegenerative and systemic diseases. Although structural information of the amyloid state is now abundant, mechanistic details about the misfolding process remain elusive. Inspired by the Φ-value analysis of protein folding, we combined experiments and molecular simulations to resolve amino-acid contacts and determine the structure of the transition-state ensemble-the rate-limiting step-for fibril elongation of PI3K-SH3 amyloid fibrils.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
November 2024
From the Biodynamic Research Corporation, San Antonio, TX (Santos, Watson), OrthoLegal, Marina Del Rey, CA (Dixon), and Department of Orthopaedics and Rehabilitation (Whang), Yale University School of Medicine, New Haven, CT.
Orthopaedic surgeons are frequently involved in treating patients with conditions resulting from occupational injuries or trauma from motor vehicle collisions. These circumstances may lead to disputes that are subject to litigation or medicolegal determinations by state agencies. As musculoskeletal experts, orthopaedic surgeons are frequently asked to opine on the causation and extent of injury in these patients.
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:
Introduction And Importance: Adenosquamous carcinoma (ASC) of the colon is a rare malignancy, representing approximately 0.06 % of colorectal cancers (CRC). It is characterized by the coexistence of adenocarcinoma and squamous cell carcinoma components.
View Article and Find Full Text PDFClin Case Rep
January 2025
Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences Okayama University Okayama Japan.
Blunt abdominal trauma causing intraperitoneal injury and/or bleeding can be life-threatening, requiring immediate intervention. Diagnosing these cases can be challenging, especially when pre-existing conditions are involved. Low-grade appendiceal mucinous neoplasm (LAMN) is a rare tumor of the appendix that can lead to pseudomyxoma peritonei.
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