Objectives: Given the high need and the absence of specific antivirals for treatment of COVID-19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 [SARS-CoV-2]), human immunodeficiency virus (HIV) protease inhibitors are being considered as therapeutic alternatives.
Methods: Prezcobix/Rezolsta is a fixed-dose combination of 800 mg of the HIV protease inhibitor darunavir (DRV) and 150 mg cobicistat, a CYP3A4 inhibitor, which is indicated in combination with other antiretroviral agents for the treatment of HIV infection. There are currently no definitive data on the safety and efficacy of DRV/cobicistat for the treatment of COVID-19. The in vitro antiviral activity of darunavir against a clinical isolate from a patient infected with SARS-CoV-2 was assessed.
Results: DRV showed no antiviral activity against SARS-CoV-2 at clinically relevant concentrations (EC > 100 μM). Remdesivir, used as a positive control, demonstrated potent antiviral activity (EC = 0.38 μM).
Conclusions: Overall, the data do not support the use of DRV for the treatment of COVID-19.
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| http://dx.doi.org/10.1016/j.ijid.2020.05.085 | DOI Listing |
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