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Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice. | LitMetric

AI Article Synopsis

  • Tissue-resident macrophages are crucial for the development and maintenance of the mammary gland, being closely linked to both the epithelial parts and the surrounding adipose tissue.
  • Researchers identified a specific subgroup of macrophages in the mammary gland that express Lyve-1, which is involved in interacting with hyaluronan, a key component of the extracellular matrix (ECM).
  • Depleting these macrophages results in an abnormal buildup of hyaluronan in the adipose stroma, highlighting their role in maintaining tissue homeostasis in the virgin mammary gland.

Article Abstract

Tissue-resident macrophages in the mammary gland are found in close association with epithelial structures and within the adipose stroma, and are important for mammary gland development and tissue homeostasis. Macrophages have been linked to ductal development in the virgin mammary gland, but less is known regarding the effects of macrophages on the adipose stroma. Using transcriptional profiling and single-cell RNA sequencing approaches, we identify a distinct resident stromal macrophage subpopulation within the mouse nulliparous mammary gland that is characterized by the expression of Lyve-1, a receptor for the extracellular matrix (ECM) component hyaluronan. This subpopulation is enriched in genes associated with ECM remodeling and is specifically associated with hyaluronan-rich regions within the adipose stroma and fibrous capsule of the virgin mammary gland. Furthermore, macrophage depletion leads to enhanced accumulation of hyaluronan-associated ECM in the adipose-associated stroma, indicating that resident macrophages are important for maintaining homeostasis within the nulliparous mammary gland stroma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297528PMC
http://dx.doi.org/10.7554/eLife.57438DOI Listing

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