AI Article Synopsis
- MUC15 is a glycosylated transmembrane protein that helps lubricate surfaces, provide a selective barrier at epithelial tissues, and facilitate cell signaling.
- Aberrant expression of MUC15 is linked to the progression of various diseases, particularly malignant tumors, and it has a complex role, acting both as a tumor suppressor and an oncogene in different cancers.
- The exact function of MUC15 in tumor development remains unclear, prompting a comprehensive review of its structure, function in cancer, and potential implications for cancer treatment.
Article Abstract
MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfaces, establishing a selective molecular barrier at the epithelium and mediating signal transduction. Aberrant expression of MUC15 plays a crucial role in the progression of multiple diseases, including malignant tumors. MUC15 has been identified as a tumor suppressor, but current evidence indicate its function as an oncogene in different types of cancers. MUC15 has been shown to be involved in the development of cancer and influence cellular growth, adhesion, invasion, metastasis and immune immunomodulation. However, the precise role of MUC15 in tumour development has not been thoroughly clarified. Here, we systematically summarize the structure and function of MUC15 in cancer, and discuss its potential role in cancer treatment.
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| http://dx.doi.org/10.2174/1568009620666200601140639 | DOI Listing |
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