AI Article Synopsis
- - Scientists showed that tiny particles can talk to each other and to cells using a special method called stigmergy.
- - They used two types of nanoparticles: one had a medicine called 9-cis-retinoic acid and another had sulforhodamine B.
- - When the first group of nanoparticles entered breast cancer cells, they helped the cells take in the second group, which then killed the cancer cells.
Article Abstract
Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)IFN) is loaded with 9-cis-retinoic acid and capped with interferon-γ, whereas the second community of nanoparticles (i.e.S(sulf)PIC) is loaded with sulforhodamine B and capped with poly(I:C). The uptake of S(RA)IFN by SK-BR-3 breast cancer cells enhanced the expression of TLR3 receptor facilitating the subsequent uptake of S(sulf)PIC and cell killing.
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| http://dx.doi.org/10.1039/d0cc02795b | DOI Listing |
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Nanoparticle-cell-nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells.
Chem Commun (Camb)
July 2020
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Spain. and CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Valencia, Spain and Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n 46022, Valencia, Spain and Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain.
Article Synopsis
- - Scientists showed that tiny particles can talk to each other and to cells using a special method called stigmergy.
- - They used two types of nanoparticles: one had a medicine called 9-cis-retinoic acid and another had sulforhodamine B.
- - When the first group of nanoparticles entered breast cancer cells, they helped the cells take in the second group, which then killed the cancer cells.
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