We examined whether change in added sugar intake is associated with change in δC, a novel sugar biomarker, in thirty-nine children aged 5-10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δC in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake was associated with change in the δC biomarker, where for every 1-g increase in added sugar intake between the two time points, there was an increase in δC of 0⋅0082 ( = 0⋅0053), independent of change in HbA1c and δN. The δC biomarker may be used as a measure of compliance in an intervention study of children under the age of 10 years who are at increased risk for type 1 diabetes, in which the goal was to reduce dietary sugar intake.
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| http://dx.doi.org/10.1017/jns.2020.9 | DOI Listing |
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