Behavioral and spinal problems have been reported to be important causes of early retirement in military working dogs, however studies on possible relationships between these two problems are currently lacking. The aim of this retrospective, observational, cross-sectional study was to test associations between reported behavioral problems and computed tomographic (CT) diagnoses of lumbosacral (LS) stenosis in a sample of military working dogs. . For each included dog, an observer unaware of CT findings reviewed medical records and recorded dog signalment data. A second observer reviewed medical records and assigned . The number of behavioral problems were significantly associated with number of vertebral locations with LS stenosis (ordinal logistic fit, p=0.011) and positively correlated (rho = 0.37, p = 0.006). Problems involving behavioral concerns were more likely to be exhibited if dogs had multi-level stenosis (≥3 vertebral levels, Kappa = 0.06, p>0.05; Bowker's test statistics 26.26, P<0.05). The most common behavior problems in dogs with multi-level stenosis were "unwilling or reluctant to jump up onto objects/into vehicles" (3/8, 38%), "sudden onset of aggressive behaviors" (2/8, 25%), "self-mutilation in the lower back region, tail, or hind legs "(2/8, 25%), "increase in anxiety" (2/8, 25%), "sudden decrease in appetite" (2/8, 25%), "unwilling or reluctant to sit" (2/8, 25%), and "handler-reported unusual behaviors" (2/8, 25%). .
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J Pain Res
January 2025
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Purpose: To develop a training program on cancer pain management for pharmacists and to evaluate the effectiveness of the training.
Methods: The program developed a well-structured curriculum and subsequent evaluation of training effectiveness, guided by the Kirkpatrick four-tier evaluation model, including reaction, learning, behavior, and results. The training approach incorporated mentoring, study groups, and problem-based learning to create an immersive and impactful learning experience.
Multiplexed Immunofluorescence (MxIF) enables detailed immune cell phenotyping, providing critical insights into cell behavior within the tumor immune microenvironment (TIME). However, signal integrity can be compromised due to the complex cyclic staining processes inherent to MxIF. Hematoxylin and Eosin (H&E) staining, on the other hand, offers complementary information through its depiction of cell morphology and texture patterns and is often visually cross-referenced with MxIF in clinical settings.
View Article and Find Full Text PDFMater Today Bio
February 2025
Department of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, Italy.
Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis.
View Article and Find Full Text PDFPsychol Res Behav Manag
January 2025
Department of Orthopedics, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Objective: This study aims to examine the relationships between social anxiety, learning adaptability, AI technology usage, and behavioral problems among primary school students, with a focus on the mediating role of learning adaptability and the moderating role of AI usage.
Methods: A cross-sectional survey was conducted among 1240 primary school students aged 8-15 in Luzhou, Sichuan Province. Social anxiety was measured using the Social Anxiety Scale for Children (SASC), learning adaptability was assessed with the Children's Learning Adaptability Questionnaire (CSAQ), behavioral problems were evaluated using the Child Behavior Checklist (CBCL), and AI tool usage was gauged through a self-developed questionnaire.
J Child Psychol Psychiatry
January 2025
Department of Applied Psychology and Human Development, University of Toronto, Toronto, Ontario, Canada.
Background: This longitudinal study with multi-informant (maternal, paternal, and experimenter) and multimethod (questionnaires, behavioral observations, and standardized assessments) data tests an intergenerational model from mothers' adverse childhood experiences (ACEs) to their children's socio-emotional and cognitive outcomes.
Methods: Participants were 501 children (50.7% male) and caregivers (56.
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