Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/liv.14551 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular Insights into the Inhibition of Lipid Accumulation in Hepatocytes by Unique Extracts of Ashwagandha.
Int J Mol Sci
November 2024
AIST-INDIA DAILAB, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8565, Japan.
We investigated the effect of purified withanolides and extracts derived from Ashwagandha on steatosis, the abnormal accumulation of fat that can lead to non-alcoholic fatty liver disease (NAFLD). Collaborator of ARF (CARF, also known as CDKN2AIP, a protein that regulates hepatic lipid metabolism, fat buildup, and liver damage) was used as an indicator. Six withanolides (Withaferin A, Withanone, Withanolide B, Withanoside IV, Withanoside V, and Withanostraminolide-12 deoxy) reversed the decrease in CARF caused by exposure to free fatty acids (FFAs) in liver-derived cells (HepG2 hepatocytes).
View Article and Find Full Text PDFAshwagandha-Induced Hepatic Injury: A Case Report.
Cureus
October 2024
Division of Nephrology, Department of Internal Medicine, Misrata Medical Center, Misrata, LBY.
A 22-year-old healthy Libyan female suffered moderate to severe liver injury following the ingestion of ashwagandha capsules. Following a latency period of 30 hours, she developed severe itching, fatigue, nausea, and jaundice. Laboratory results showed significantly increased liver enzymes (especially alanine aminotransferase (ALT)) and bilirubin (mainly conjugated bilirubin), along with a slight elevation of alkaline phosphatase (ALP).
View Article and Find Full Text PDFAnti-inflammatory and anti-angiogenic effects of extract on liver toxicity induced by silver nanoparticles in vivo.
J Med Life
July 2024
Faculty of Medicine, Al-Baha University, Al-Baha, KSA.
Article Synopsis
- The study investigates the effects of a specific extract on liver toxicity caused by silver nanoparticles (AgNPs) in mice, focusing on anti-inflammatory, anti-angiogenic, and hepatoprotective properties.
- Fifty Swiss mice were divided into five groups to assess various treatment regimens, including a control group, one receiving the extract, and multiple groups exposed to AgNPs with or without the extract.
- Results showed that the extract significantly improved liver function, reduced inflammation, and exhibited hepatoprotective effects in the group that received it after AgNP exposure, indicating its potential as a treatment for liver damage.
Liver toxicity and repair evaluated by histopathology and electric modulus.
Toxicol Res (Camb)
October 2024
Department of Microwave Physics and Dielectrics, National Research Centre, 33 Elbohouth St., Dokki, P.O. 12622, Giza, Egypt.
Detoxification is one of the most important liver functions. Therefore, liver is the front line of defense when the biosystem faces drug overdose, toxins, and anything that may cause harm. Some famous antibiotics are known for their side effects on liver; one of them is amoxicillin, AM.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!