Background: Federal law mandates complete insurance coverage for breast reconstruction and considers it an "essential" aspect of breast cancer treatment, on par with mastectomy and chemotherapy. Unfortunately, a significant proportion of women do not undergo reconstruction. The objective of this study is to assess care gaps in breast cancer treatment and reconstruction in rural populations.
Methods: All hospitals in Upstate New York were surveyed regarding what components of breast cancer care they provide, including breast surgery, medical oncology, radiation oncology, and plastic surgery. Survey results were correlated with population data to determine how many women might be impacted by geographic barriers to care.
Results: Of 135 hospitals, only 56% offered any component of breast cancer treatment, while 30% offer breast surgery, 44% offer radiation oncology, and 42% offer plastic surgery. Microsurgical breast reconstruction was offered at just 14% of hospitals. Only 11% of hospitals were complete cancer care centers, which offer all the essential elements of breast cancer care (breast surgery, reconstructive surgery, medical oncology, and radiation) and all reconstructive options (including microvascular). Based on population data, 21% of Upstate New Yorkers live in counties without access to any form of breast reconstruction, 44% live in counties without microsurgical reconstruction, 30% live in counties without a hospital that staffs all members of the cancer care team, and 47% live in counties without a complete cancer care center.
Conclusions: Geographic barriers play a large role in the lack of access to breast cancer care and reconstruction.
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http://dx.doi.org/10.1016/j.jss.2020.04.035 | DOI Listing |
Cancer Causes Control
December 2024
Department of Clinical Nutrition, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
Breast cancer is the leading cause of cancer-related death and the most common cancer among women worldwide. It is crucial to identify potentially modifiable risk factors to intervene and prevent breast cancer effectively. Sleep factors have emerged as a potentially novel risk factor for female breast cancer.
View Article and Find Full Text PDFDaru
December 2024
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Objective(s): Some forms of breast cancer such as triple-negative phenotype, are serious challenge because of high metastatic cases, high mortality and resistance to conventional therapy motivated the search for alternative treatment approaches. Nanomaterials are promising candidates and suitable alternatives for improving tumor and cancer cell treatments.
Materials And Methods: Biosynthesis of ZnO NPs by help of Berberis integerrima fruit extract, has been done.
J Med Chem
December 2024
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.
View Article and Find Full Text PDFACS Biomater Sci Eng
December 2024
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
Polymer based nanoformulations offer substantial prospects for efficacious chemotherapy delivery. Here, we developed a pH-responsive polymeric nanoparticle based on acidosis-triggered breakdown of boronic ester linkers. A biocompatible hyaluronic acid (HA) matrix served as a substrate for carrying a doxorubicin (DOX) prodrug which also possesses natural affinity for CD44 cells.
View Article and Find Full Text PDFACS Nano
December 2024
The Fifth Affiliated Hospital, Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, the School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Tumor-specific cytotoxic T cell immunity is critically dependent on effective antigen presentation and sustained signal transduction. However, this immune response is frequently compromised by the inherently low immunogenicity of breast cancer and the deficiency in major histocompatibility complex class I (MHC-I) expression. Herein, a chimeric peptide-engineered stoichiometric polyprodrug (PDPP) is fabricated to potentiate the cytotoxic T cell response, characterized by a high drug loading capacity and precise stoichiometric drug ratio, of which the immunogenic cell death (ICD) inducer of protoporphyrin IX (PpIX) and the epigenetic drug of decitabine (DAC) are condensed into a polyprodrug called PpIX-DAC.
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