AI Article Synopsis
- Researchers studied a tiny molecule called miR-4262 in patients with esophageal cancer to see how it affects their health and cancer development.
- They found that lower levels of miR-4262 in cancer samples were linked to worse disease stages and outcomes for patients.
- Increasing miR-4262 in cancer cells helped slow down their growth and caused more of them to die, suggesting it could be important for treating esophageal cancer.
Article Abstract
Objective: To uncover the expression pattern and the prognosis of miR-4262 in these patients with esophageal cancer, and its potential mechanism.
Methods: MiR-4262 levels in 57 esophageal cancer and paracancerous specimens were detected. The relationship between miR-4262 level and clinical features of esophageal cancer was analyzed. After overexpression of miR-4262 in OE19 and EC-109 cells, changes in proliferative potential and apoptosis were examined. The interaction between miR-4262 and KLF6 was explored by dual-luciferase reporter assay. Their involvement in the development of esophageal cancer was finally determined.
Results: MiR-4262 was downregulated in esophageal cancer specimens and cell lines. Low level of miR-4262 predicted advanced pathological staging and poor prognosis in esophageal cancer patients. Overexpression of miR-4262 reduced proliferative potential and enhanced apoptosis in esophageal cancer cells. KLF6 was the downstream gene binding to miR-4262. The interaction between miR-4262 and KLF6 was responsible for alleviating the malignant development of esophageal cancer.
Conclusions: MiR-4262 is downregulated in esophageal cancer and linked to its pathological staging and prognosis. MiR-4262 inhibits the malignant development of esophageal cancer by down-regulating KLF6.
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| http://dx.doi.org/10.1016/j.yexmp.2020.104476 | DOI Listing |
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