Health Phenotypes and Neurobehavioral Symptom Severity Among Post-9/11 Veterans With Mild Traumatic Brain Injury: A Chronic Effects of Neurotrauma Consortium Study.

J Head Trauma Rehabil

Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina (Dr Bouldin); Department of Psychology, University of Texas at San Antonio (Dr Swan); Speech-Language Pathology Program, School of Health Professions, University of Texas Health Science Center at San Antonio (Dr Norman); George E. Whalen VA Medical Center, Salt Lake City, Utah (Dr Tate); Departments of Neurology (Dr Tate) and Internal Medicine (Dr Pugh), University of Utah School of Medicine, Salt Lake City; Lees-McRae College, Banner Elk, North Carolina (Ms Tumminello); VA Salt Lake City Health Care System, Informatics, Decision-Enhancement, and Analytic Sciences Center, Salt Lake City, Utah (Mss Amuan and Trevino and Dr Pugh); Department of Physical Medicine and Rehabilitation, VA Greater Los Angeles Health Care System, and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (Dr Eapen); and Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio (Dr Wang).

Published: October 2021

Objective: To evaluate whether neurobehavioral symptoms differ between groups of veterans with mild traumatic brain injury (mTBI) classified by health characteristics.

Participants: A total of 71 934 post-9/11 veterans with mTBI from the Chronic Effects of Neurotrauma Consortium Epidemiology warfighter cohort.

Design: Cross-sectional analysis of retrospective cohort.

Main Measures: Health phenotypes identified using latent class analysis of health and function over 5 years. Symptom severity measured using Neurobehavioral Symptom Inventory; domains included vestibular, somatic, cognitive, and affective.

Results: Veterans classified as moderately healthy had the lowest symptom burden while the polytrauma phenotype group had the highest. After accounting for sociodemographic and injury characteristics, polytrauma phenotype veterans had about 3 times the odds of reporting severe symptoms in each domain compared with moderately healthy veterans. Those veterans who were initially moderately healthy but whose health declined over time had about twice the odds of severe symptoms as consistently healthier Veterans. The strongest associations were in the affective domain. Compared with the moderately healthy group, veterans in other phenotypes were more likely to report symptoms substantially interfered with their daily lives (odds ratio range: 1.3-2.8).

Conclusion: Symptom severity and interference varied by phenotype, including between veterans with stable and declining health. Ameliorating severe symptoms, particularly in the affective domain, could improve health trajectories following mTBI.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649312PMC
http://dx.doi.org/10.1097/HTR.0000000000000574DOI Listing

Publication Analysis

Top Keywords

moderately healthy
16
symptom severity
12
severe symptoms
12
veterans
10
health phenotypes
8
neurobehavioral symptom
8
post-9/11 veterans
8
veterans mild
8
mild traumatic
8
traumatic brain
8

Similar Publications

Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.

Brain Struct Funct

January 2025

Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond Street, North London, ON, N6A 5C1, Canada.

The dual task cost of gait (DTC) is an accessible and cost-effective test that can help identify individuals with cognitive decline and dementia. However, its neural substrate has not been widely described. This study aims to investigate the neural substrate of the high DTC in older adults across the spectrum of cognitive decline.

View Article and Find Full Text PDF

Background: Exposure to community violence is associated with increased occurrence of substance use disorders (SUD). The self-medication hypothesis states that heightened negative emotionality may underlie the link between exposure to community violence and SUD. However, it is not well-understood if access to community resources, a broader public health approach, influences the purported psychological mechanisms underlying the link between community violence exposure and SUD.

View Article and Find Full Text PDF

Physical activity (PA) reduces the risk of negative mental and physical health outcomes in older adults. Traditionally, PA intensity is classified using METs, with 1 MET equal to 3.5 mL O·min·kg.

View Article and Find Full Text PDF

The Pupillary Light Reflex (PLR) is the involuntary movement of the pupil adapting to lighting conditions. The measurement and qualification of this information have a broad impact in different fields. Thanks to technological advancements and algorithms, obtaining accurate and non-invasive records of pupillary movements is now possible, expanding practical applications.

View Article and Find Full Text PDF

Background: Sleep dysfunction is commonly seen in Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP), potentially worsening these conditions. Investigating early neuropathological changes in human sleep-promoting neurons, which often precede cognitive decline, is crucial for understanding the basis for sleep dysfunction as possible treatments yet remain underexplored. We used postmortem brains of AD and PSP patients to quantify neuronal numbers and tau burden in the intermediate nucleus of the hypothalamus (IntN), VLPO analog, known for its role in sleep maintenance.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!