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Exploring methandienone metabolites generated via homogenized camel liver: Advancements for anti-doping applications through High Resolution-Liquid Chromatography Mass Spectrometry analysis.
Rapid Commun Mass Spectrom
December 2024
Camel Forensic Laboratory, Central Veterinary Research Laboratory, Dubai, 597, United Arab Emirates.
Rationale: Anabolic steroids, also known as anabolic-androgenic steroids (AAS), encompass steroidal androgens such as testosterone, as well as synthetic counterparts with similar structures and effects. The misuse of AAS has increased over the years, leading to ethical and welfare concerns in sports. The World Anti-Doping Agency (WADA) and the International Federation for Equestrian Sports (FEI) have banned AAS in relevant sports.
View Article and Find Full Text PDFChanging trends in anabolic-androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation.
Drug Test Anal
August 2024
Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, UK.
Anabolic-androgenic steroids (AASs) are a subclassification of image performance enhancing drugs (IPEDs). While AAS use is most prevalent among people in athletics, there is also high lifetime prevalence of AAS use among prisoners. This study reports the qualitative detection of AASs in seized samples from the Scottish prisons from 2019-2023.
View Article and Find Full Text PDFThe elucidation of the metabolic fate of prohibited substances is crucial for the abuse detection. The human hepatocyte cell line HepG2 can be used to study biotransformation. In order to improve this in vitro model system, we compared the HepG2 spheroid generation using three different techniques: a forced floating, a scaffold-free and a scaffold-based method.
View Article and Find Full Text PDFExperimental studies on androgen administration in animal models: current and future perspectives.
Curr Opin Endocrinol Diabetes Obes
December 2022
Department of Medical, Surgical and Advanced Technologies 'G.F. Ingrassia', University of Catania, Catania, Italy.
Purpose Of Review: This review aims to report the most recent (2020-2022) experimental scientific studies conducted on animal models, in order to highlight the relevant findings on the adverse effects related to androgen administration.
Recent Findings: Forty-one studies published between January 2020 and July 2022 were selected. The majority of studies investigated the effects of one androgen, whereas only four studies analyzed the effects of two drugs.
A Highly Sensitive Modified Glassy Carbon Electrode with a Carboxylated Multi-walled Carbon Nanotubes/Nafion Nano Composite for Voltammetric Sensing of Dianabol in Biological Fluid.
Anal Sci
December 2021
Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah, 21589, Saudi Arabia.
The extraordinary prerequisite for the analysis of an anabolic steroid, namely dianabol (DB), has inspired towards the development of a cost-effective and high-performance sensing probe. Thus, a simple and robust electrochemical sensor (c-MWCNTs-NafionlGCE) for dianabol (DB), a widely used steroid, was developed using a glassy carbon electrode (GCE) modified with functionalized carboxylated multi-walled carbon nanotubes (c-MWCNT) and Nafion. At pH 7 - 8, differential pulse-cathodic stripping voltammetry (DP-CSV) displayed two cathodic peaks at -0.
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