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[Identification and Analysis of Irregular Antibodies in Hospitalized Patients Prepared to Accept Blood Transfusion].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Blood Transfusion, The Second Hospital of Shandong University, Jinan 250033， Shandong Province， China.
Objective: To analyze the type and distribution characteristics of irregular antibodies in 71 847 hospitalized patients who prepared to accept blood transfusion, and to explore their role in safe blood transfusion.
Methods: 71 847 patients who applied for red blood transfusion from January 2020 to October 2023 were selected. All specimens were screened and identified for the irregular antibody by microcolumn gel antiglobulin technique.
Transfusing selected RhD negative patients with RhD positive packed red cell concentrates resulted in lower frequency of anti-D development and saved almost two thousand RhD negative concentrates during 5 years.
Transfus Med
December 2024
Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
Background: The Blood Bank at Oslo University Hospital implements restrictions when the stocks of blood groups O and A RhD negative packed red blood cell concentrates (PRBCCs) drop below 60 units due to high demand and low donor availability. Restrictions entail transfusing RhD negative male patients and women >50 years with RhD positive units, to provide RhD negative units to those who should not receive RhD positive units. Earlier studies have reported that up to 50% of RhD negative patients developed anti-D after RhD positive blood transfusion.
View Article and Find Full Text PDFRhD-positive red blood cell allocation practice to RhD-negative patients before and during the COVID-19 pandemic.
Am J Clin Pathol
September 2024
Department of Laboratory Medicine and Pathology, Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, US.
Article Synopsis
- * A survey distributed to physicians revealed that most institutions did not change their policies regarding the selection of pRBCs in RhD-negative patients during the pandemic, with 83.87% of policies remaining the same.
- * Despite challenges in the supply of RhD-negative pRBCs, many respondents (53.85%) reported offering Rh immunoglobulin to Rh-negative patients who received RhD-positive pRBCs, indicating some variability in practices.
A Concise Guide to D-Wave Monitoring during Intramedullary Spinal Cord Tumour Surgery.
Medicina (Kaunas)
July 2024
Department of Neurosurgery, Inselspital, Bern University Hospital, and University of Bern, 3010 Bern, Switzerland.
D-waves (also called direct waves) result from the direct activation of fast-conducting, thickly myelinated corticospinal tract (CST) fibres after a single electrical stimulus. During intraoperative neurophysiological monitoring, D-waves are used to assess the long-term motor outcomes of patients undergoing surgery for intramedullary spinal cord tumours, selected cases of intradural extramedullary tumours and surgery for syringomyelia. In the present manuscript, we discuss D-wave monitoring and its role as a tool for monitoring the CST during spinal cord surgery.
View Article and Find Full Text PDF[Analysis of the causes of incompatible cross-matching induced by two Rh blood group antibodies and corresponding laboratory treatment].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
July 2024
Department of Blood Transfusion, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. *Corresponding authors, E-mail:
Objective To analyze the serological characteristics and clinical significance of IgG anti-D and anti-C combined antibodies and anti-E and anti-c combined antibodies in patients negative for RhDC and RhEc antigens. Methods The clinical data and laboratory results of 12 cases with two types of irregular antibodies were recorded and analyzed, including age, sex, history of blood transfusion/pregnancy, ABO and RhD blood group identification, Rh antigen typing, irregular antibody screening, antibody-specific identification, absorption-elution tests, antibody titer determination and cross-matching tests. Results Among the 12 patients, the mean age was 51.
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