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Phylodynamics of G4P[8] and G2P[4] strains of rotavirus A isolated in Russia in 2017 based on full-genome analyses. | LitMetric

AI Article Synopsis

  • Rotavirus A is a virus that causes severe stomach infections in young children and is actively changing over time, particularly noted in strains found in Russia in 2017.
  • The study analyzed the genetic sequences of two rotavirus genotypes, G4P[8] and G2P[4], using a Bayesian method to trace the origins of each genetic segment to various countries.
  • The findings show that the most recent common ancestors of the G4P[8] and G2P[4] strains existed in different time frames (2001-2012 for G4P[8] and 2006-2013 for G2P[4]), with their ancestors traced back to both local and global locations.

Article Abstract

Rotavirus A is a dynamically evolving pathogen causing acute gastroenteritis in children during the first years of life. In the present study, we conducted a phylodynamic analysis based on the complete sequences of 11 segments of rotaviruses with the G4P[8] and G2P[4] genotypes isolated in Russia in 2017. Since rotavirus has a segmented genome, our analysis was performed using the Bayesian approach based on separate samples of nucleotide sequences for each gene of the strains studied. For the strain with the genotype G4P[8], the most likely geographical locations of the nearest common ancestor were Russia (VP7, VP4, VP6), China (VP1), Thailand (VP3), Belgium (NSP1), Hungary (VP2, NSP2, NSP3), Italy (NSP4) and Japan (NSP5). For the strain with the G2P[4] genotype, India (VP7, VP4, VP6, NSP1, NSP4), Malawi (VP2, NSP2, NSP3), Australia (VP1), Italy (NSP5) and Bangladesh (VP3). The closest common ancestor of the strain with the genotype G4P[8] circulated in 2001-2012, depending on the gene being analyzed. For the strain with the G2P[4] genotype, the closest common ancestor dates from 2006 to 2013.

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Source
http://dx.doi.org/10.1007/s11262-020-01771-3DOI Listing

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