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| http://dx.doi.org/10.1007/s00134-020-06105-3 | DOI Listing |
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Evaluating metagenomic analyses for undercharacterized environments: what's needed to light up the microbial dark matter?
bioRxiv
November 2024
Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Non-human-associated microbial communities play important biological roles, but they remain less understood than human-associated communities. Here, we assess the impact of key environmental sample properties on a variety of state-of-the-art metagenomic analysis methods. In simulated datasets, all methods performed similarly at high taxonomic ranks, but newer marker-based methods incorporating metagenomic assembled genomes outperformed others at lower taxonomic levels.
View Article and Find Full Text PDFWhat's hot in neonatal respiratory monitoring?
Pediatr Res
November 2024
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Respiratory monitoring is an essential part of routine clinical care of the newborn. Recent technological developments have improved respiratory monitoring and allowed for a two-way interaction between the monitored parameter and the level of the provided respiratory support. We herein discuss applications of monitoring by neurally adjusted ventilatory assist, closed-loop oxygen control, tidal capnography, lung ultrasound, diaphragmatic electromyography and lung magnetic resonance imaging.
View Article and Find Full Text PDFSarcoidosis: A Review of the Guidelines and What's To Come.
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Assistant Professor, Pulmonary and Critical Care Fellow, Department of Pulmonary and Critical Care Medicine, University Health Hospital, University of Missouri-Kansas City, Kansas City, Missouri.
Sarcoidosis is a disease hallmarked by granulomatous inflammation of nearly all organ systems. Though it has been widely recognized for over 100 years, much remains unknown about the etiology and pathophysiology of the disease. Due in part to this is ambiguity, diagnosis and treatment, algorithms have been difficult to create and even harder to develop a strong evidence base for.
View Article and Find Full Text PDFChronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension.
Respir Res
September 2024
Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266071, China.
Article Synopsis
- - Diesel exhaust (DE) is a major traffic-related pollutant linked to increased risks for heart and lung diseases, but its specific effects on the small pulmonary vessels remain uncertain.
- - A study analyzed pulmonary vessel changes in workers exposed to DE and used a rat model to further investigate chronic DE exposure's impact, finding significant changes in pulmonary vessel structure and function.
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GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor.
J Nanobiotechnology
September 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Article Synopsis
- Phototherapy, which includes photothermal therapy (PTT) and photodynamic therapy (PDT), faces challenges in effectiveness due to tumor hypoxia and the presence of immunosuppressive factors like IDO and PD-L1.
- Researchers developed multifunctional polymeric micelles called RIMNA to deliver a combination of treatments: the photosensitizer ICG, an oxygenator MnO, an IDO inhibitor NLG919, and an immune stimulant MPLA.
- RIMNA showed strong stability and biocompatibility, and effectively improved phototherapy outcomes by enhancing immune activation and reducing tumor growth, indicating a promising strategy for improving cancer treatment.
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