AI Article Synopsis
- Two new milbemycin derivatives were discovered: 5,27-epoxy-13α-hydroxy milbemycin β (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β (2).
- They were isolated from a genetically engineered strain of bacteria known as Streptomyces avermitilis AVE-H39.
- The structures of these compounds were determined using HR-ESIMS and NMR spectroscopic analysis, and they showed moderate effectiveness in killing mites (acaricidal) and nematodes (nematicidal).
Article Abstract
Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.
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| http://dx.doi.org/10.1038/s41429-020-0317-2 | DOI Listing |
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