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The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.
Clin Transl Med
January 2025
Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu, China.
Background: Hypoxia can affect the occurrence and development of inflammation in humans, but its effects on the disease progression of osteoarthritis (OA) remain unclear. Synovial macrophages play an essential role in the progression of arthritis. Specifically, the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) in macrophages induces the secretion of a series of inflammatory factors, accelerating the progression of OA.
View Article and Find Full Text PDFReduced sensitivity to cocaine effects and changes in mesocorticolimbic dopamine receptors in adolescent sexually active female rats.
Psychopharmacology (Berl)
December 2024
Evolutionary Genetics Department, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Rationale: The sexual behavior of the female rat is highly motivated, and the mesocorticolimbic dopaminergic system -involved in psychostimulants effects- has been implicated in its regulation. Female rats begin to express sexual behavior during adolescence, a period during which this system is not yet mature.
Objective: To examine the impact of cocaine on sexual motivation and behavior of adolescent and adult female rats, and to determine the dopamine receptors binding in mesocorticolimbic areas of these females.
Comparison of Self-repair Disparities in Articular Cartilage Defect Models With Various Load-bearing Sites.
J Craniofac Surg
December 2024
Department of Endocrinology and Metabolism, West China Hospital, Chengdu, China.
This study aimed to explore the construction of experimental animal models replicating cartilage defects across diverse load-bearing sites, compare self-repair conditions, and examine the role of mechanical stimulation in cartilage self-repair. Experimental animal models were established in rabbits to simulate full-thickness cartilage defects without penetrating the subchondral bone, at various load-bearing sites, including the posterior femoral condyle, anterior femoral condyle and femoral trochlear of knee joint, and the humerus of the shoulder joint. The successful exposure and construction of cartilage defects at the anterior femoral condyle, femoral trochlear, and posterior femoral condyle through the medial extension of surgical incision.
View Article and Find Full Text PDFImpact of Five Weeks of Strengthening Under Blood Flow Restriction (BFR) or Supplemental Oxygen Breathing (Normobaric Hyperoxia) on the Medial Gastrocnemius.
J Funct Morphol Kinesiol
December 2024
Environmental, Occupational, Aging (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), 1160 Brussels, Belgium.
This study investigates the effects of a five-week training program on the medial gastrocnemius muscle, comparing two approaches: blood flow restriction (BFR) training and normobaric hyperoxia (oxygen supplementation). It evaluates three strengthening modalities (dynamic, isometric, and the 3/7 method) analyzing their impact on maximal voluntary contraction (MVC), muscle architecture, and perceived exertion. A total of 36 young healthy participants (21 females, 15 males) were randomized into six subgroups (n = 6 each) based on the type of contraction and oxygen condition.
View Article and Find Full Text PDFEffect of Ankle-Foot Orthosis on Paretic Gastrocnemius and Tibialis Anterior Muscle Contraction of Stroke Survivors During Walking: A Pilot Study.
Biosensors (Basel)
December 2024
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Ankle-foot orthoses (AFOs) have been commonly prescribed for stroke survivors with foot drop, but their impact on the contractions of paretic tibialis anterior (TA) and medial gastrocnemius (MG) has remained inconclusive. This study thus investigated the effect of AFOs on these muscle contractions in stroke survivors. The contractions of paretic TA and MG muscles were assessed in twenty stroke patients and compared between walking with and without AFOs, using a novel wearable dynamic ultrasound imaging and sensing system.
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