AI Article Synopsis
- Streptococcus pneumoniae associated hemolytic uremic syndrome (Sp-HUS) is characterized by anemia, low platelet count, and acute kidney injury following an invasive infection with Streptococcus pneumoniae.
- A 2-year-old boy with pneumonia developed symptoms like pallor, weakness, and decreased urine output after being hospitalized; lab tests showed severe anemia and kidney dysfunction.
- The patient's condition improved with mechanical ventilation and blood transfusions, and Sp serotype 38 was identified, marking the first documented instance of this serotype linked to Sp-HUS.
Article Abstract
Streptococcus pneumoniae associated hemolytic uremic syndrome (Sp-HUS) is defined as microangiopathic hemolytic anemia, thrombocytopenia and acute renal injury, in a patient with Streptococcus pneumoniae (Sp) invasive infection. A 2-year-old boy was admitted with pneumonia and empyema. Sp was isolated from blood and pleural fluid cultures. After 72 h, the patient showed paleness, asthenia, respiratory whining and oliguria. Laboratory showed anemia, low platelets, increased blood urea, creatirnina, lactate dehdrogenase, direct Coombs +, schistocytes, fibrinogen, normal coagulogram and increased D-dimer. Proteinuria and hematuria were detected in urine. Mechanical ventilatory assistance and transfusions of washed red blood cells were required. The patient recovered progressively. Sp serotype 38 was isolated in the National Reference Laboratory "Malbran". This is the first report associated to this serotype.
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| http://dx.doi.org/10.5546/aap.2020.e305 | DOI Listing |
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