Application of CpTiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to []-Annelated Indoles.

An efficient and novel route for assembling pyrrolo/piperido[1,2-]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of -tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of -fused indole derivatives with versatile functional and structural diversity.