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Time to regional surgical care in rural South Africa.
S Afr J Surg
December 2024
Centre for Global Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Background: District hospitals in South Africa have limited surgical capacity and regional hospitals treat most essential surgical conditions. This study aimed to describe the pathway and time to regional hospital surgical care for persons with general surgery conditions (PSC) in South Africa.
Methods: This was a retrospective audit of all persons referred on the Vula Mobile App to the general surgery service at Worcester Regional Hospital (WRH) from 1 January 2019 to 31 December 2019.
Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis (ALS) by Investigating Patient's Specific microRNAs as Novel Biomarkers: A Clinical Trial Study.
Curr Stem Cell Res Ther
January 2025
Department of Immunology, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Since there is currently no cure for amyotrophic lateral sclerosis (ALS), it is essential to search for diagnostic biomarkers and novel treatments to reduce the severity of this disease. One of these treatment approaches is stem cell transplantation.
Objective: This study aims to evaluate the safety and efficacy of repeated transplantation of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with ALS by analyzing clinical and molecular data.
A Prognostic Riskscore Model Related to Infection in Stomach Adenocarcinoma.
Int J Genomics
January 2025
Department of General Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing Key Laboratory of Emergency Medicine, Chongqing, China.
() is associated with the development of various stomach diseases, one of the major risk factors for stomach adenocarcinoma (STAD). The infection score between tumor and normal groups was compared by single-sample gene set enrichment analysis (ssGSEA). The key modules related to infection were identified by weighted gene coexpression network analysis (WGCNA), and functional enrichment analysis was conducted on these module genes.
View Article and Find Full Text PDFTherapeutic potential of against monkeypox: antioxidant, anti-inflammatory, and computational insights.
Front Chem
January 2025
NanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
Background: Monkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agents. (turmeric) is a widely used medicinal plant known for its antioxidant and anti-inflammatory properties, primarily attributed to its bioactive curcuminoids.
Aim: This study aimed to evaluate the therapeutic potential of aqueous extract (CAE) against monkeypox through phytochemical characterization, biological assays, and computational analyses.
Biologic Augmented Scaffold-based cartilage repair: Addressing Complications and Enhancing Outcomes.
J Clin Orthop Trauma
March 2025
Department of Orthopaedic Surgery, Sengkang General Hospital, Singapore.
Cartilage repair remains a significant challenge due to the tissue's limited innate regenerative capacity. Despite advances in techniques such as microfracture, autologous chondrocyte implantation (ACI), and osteochondral grafting, long-term outcomes are often compromised by complications, including suboptimal tissue integration, graft resorption, and mechanical instability. Recently, biologically augmented scaffold-based cartilage repair has emerged as a promising approach for full-thickness osteochondral lesions.
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