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Biofilm characterisation of Mycoplasma bovis co-cultured with Trueperella pyogenes.
Vet Res
January 2025
Animal Health Unit, Department of Veterinary Science, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Mycoplasma pneumonia, caused by Mycoplasma bovis (Mycoplasmopsis bovis; M. bovis), is linked with severe inflammatory reactions in the lungs and can be challenging to treat with antibiotics. Biofilms play a significant role in bacterial persistence and contribute to the development of chronic lesions.
View Article and Find Full Text PDFAPOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease.
J Neuroinflammation
January 2025
Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, 85013, USA.
The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. However, its effects on the lipid transporters apolipoprotein E (ApoE) and fatty acid-binding protein 7 (Fabp7), which are crucial for the maintenance of myelin in white matter (WM) during the progression of AD remain underexplored. To evaluate the effects of APOEε4 on ApoE, Fabp7 and myelin in the WM of the frontal cortex (FC), we examined individuals carrying one ε4 allele that came to autopsy with a premortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI) and mild to moderate AD compared with non-carrier counterparts.
View Article and Find Full Text PDFThe mechanism of serum cell-free DNA release in postmortem subjects and novel markers to estimate the postmortem intervals.
J Forensic Leg Med
January 2025
Department of Legal Medicine, Shimane University Faculty of Medicine, 89-1 Enya, Izumo, Shimane, 693-8501, Japan. Electronic address:
Cell-free DNA (cfDNA) is DNA released from dying cells into the serum. The aim of the present study is to elucidate the mechanism of cell-free DNA (cfDNA) release in postmortem subjects by assaying Cytokeratin 18 (M30 and M65), cyclophilin A (CyPA), and myeloperoxidase (MPO) levels and to evaluate whether these levels are useful as markers for estimating postmortem intervals. Serum (n = 54) was sampled from postmortem autopsied Japanese subjects.
View Article and Find Full Text PDFThe diagnosis of SARS-CoV-2-related myocarditis requires confirmation by endomyocardial biopsy or autopsy.
Cardiol Young
January 2025
Second Medical Department, Krankenanstal Rudolfstiftung, Vienna, Austria.
Peripartum Cardiomyopathy and Takotsubo Cardiomyopathy: Rare Contributors to Cardiac Causes of Maternal Mortality.
Cureus
December 2024
Neurology, Mercy Hospital Springfield, Springfield, USA.
Peripartum cardiomyopathy (PPCM) and takotsubo cardiomyopathy (TCM) are cardiac conditions that can occur in the peripartum period. They have distinct characteristics and incidence rates; although rare, both contribute to the second leading cause of all-cause maternal mortality in the state of Missouri. PPCM can lead to heart failure, and TCM can cause acute arrhythmias leading to sudden cardiac death in otherwise healthy individuals.
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