AI Article Synopsis
- This study explored the link between dietary zinc intake and the development of Crohn's disease (CD) and ulcerative colitis (UC).
- Among over 105,000 participants, those with higher zinc intake showed a lower risk of developing CD, while no significant connection was found for UC.
- The findings suggest that increasing dietary zinc may reduce the risk of developing CD, emphasizing the importance of nutrition in disease prevention.
Article Abstract
Introduction: This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake.
Methods: NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC.
Results: Among the 105,832 participants, 27 reported incident CD and 48 reported incident UC. The relative risks of CD decreased with dietary zinc intakes. Compared with participants with the lowest tertile of zinc intake, the relative risks for CD were 0.60 (95% confidence interval [0.22-1.66]) and 0.12 (95% confidence interval [0.02-0.73]) for the second and the highest tertiles, respectively (Ptrend = 0.02). No significant association was observed for UC.
Discussion: Dietary zinc intake was inversely associated with incident CD.
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| http://dx.doi.org/10.14309/ajg.0000000000000688 | DOI Listing |
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