AI Article Synopsis
- PFASs are man-made chemicals that can persist in the environment and disrupt endocrine functions, potentially affecting male reproductive health.
- The review highlights how PFAS exposure during pregnancy and early life impacts the development and function of Leydig cells in rodents, which are crucial for male hormone production.
- Additionally, it examines human studies on the influence of PFASs on male hormone levels and explores the relationship between the chemical structure of PFASs and their effects on Leydig cell steroid production.
Article Abstract
Perfluoroalkyl substances (PFASs) are a group of man-made organic substances. Some of PFASs have been classified as persistent organic pollutants and endocrine disruptors. They might interfere with the male sex endocrine system, causing the abnormal development of the male reproductive tract and failure of pubertal onset and infertility. The present review discusses the development and function of two generations of Leydig cells in rodents and the effects of PFASs on Leydig cell development after their exposure in gestational and postnatal periods. We also discuss human epidemiological data for the effects of PFASs on male sex hormone levels. The structure-activity relationship of PFASs on Leydig cell steroidogenesis and enzyme activities are also discussed.
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| http://dx.doi.org/10.1016/j.chemosphere.2020.126764 | DOI Listing |
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