AI Article Synopsis
- The study examined the use, effectiveness, and safety of assisted reproductive techniques (ART) across 188 institutions in 15 Latin American countries during 2017, collecting data from almost 94,000 treatment cycles.
- Of the initiated ART cycles, there were around 17,000 deliveries resulting in over 20,000 babies, with various delivery rates for different embryo transfer methods, notably single and double embryo transfers showing varying success rates.
- The findings highlight a trend toward increased use of frozen embryo transfers and single embryo transfers, particularly stressing the importance of elective single transfers to reduce risks, especially for younger women and those with multiple blastocysts available.
Article Abstract
Research Question: What was the utilization, effectiveness and safety of assisted reproductive techniques performed in Latin America during 2017.
Design: Retrospective collection of multinational data on ART performed in 188 institutions from 15 Latin American countries.
Results: We are reporting 93,600 initiated cycles, 16,976 deliveries and the birth of 20,404 babies. ART utilization was 221 cycles/million inhabitants (15 to 535). Despite women aged ≥40 represented 30.5% of fresh IVF/ICSI, after removing freeze-all cycles, delivery rate per oocyte retrieval was 19.9% for ICSI and 20.2% for IVF. Overall, single embryo transfer (SET) represented 26.9% of fresh transfers, with 18.2% delivery rate per transfer; increasing to 32.3% in elective SET. Delivery rate in double embryo transfers (DET) was 28.3% increasing to 37.3% with elective DET. This 5% increment in births in eDET over eSET resulted in10-fold increase in twin births, almost 3 weeks' shorter gestations and 3-fold increase in perinatal mortality. Delivery rate in frozen/thawed SET, reached 25.5% increasing to 30.8% with DET; the majority being blastocysts transfers. Of all births, 67% were singletons, 31.4% twins, and 1.6% triplets and higher. Overall, preterm deliveries reached 9.5% in singletons, 64.3% in twins and 97.9% in triplets; and perinatal mortality was 9.4‰ in singletons, 25.3‰ in twins, and 63.3‰ in high-order multiples.
Conclusions: The number of initiated cycles slowly increases. Frozen embryo transfers, blastocyst transfers and SET are also increasing. Our data shows that especially in young women and oocyte recipients, when there is more than one blastocyst for transfer, elective SET should be the rule.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365541 | PMC |
| http://dx.doi.org/10.5935/1518-0557.20200029 | DOI Listing |
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