AI Article Synopsis
- Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often occur together and have genetic components influencing their risk.
- In a study of 39 families, researchers found that known genetic variants explained about 10% of the variance in comorbid ASD/ADHD, with lower contributions for ASD (4%) and ADHD (2%) individually.
- The study indicates that individuals with adult ASD/ADHD needing ongoing specialist care carry a higher burden of rare genetic variants compared to unaffected family members, while affected relatives show intermediate levels.
Article Abstract
Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are highly heritable neurodevelopmental disorders that frequently co-occur. Both rare and common genetic variants are important for ASD and ADHD risk but their combined contribution to clinical heterogeneity is unclear. In a sample of 39 ASD and/or ADHD families we estimated the overall variance explained by known rare copy number variants (CNVs) and polygenic risk score (PRS) from common variants to be 10% in comorbid ASD/ADHD, 4% in ASD and 2% in ADHD. We show that burden of large, rare CNVs and PRS is significantly higher in adult ASD and/or ADHD patients with sustained need for specialist care compared to their unaffected relatives, while affected relatives fall in-between the two.
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| http://dx.doi.org/10.1007/s10803-020-04552-x | DOI Listing |
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