AI Article Synopsis
- TAVI is a viable alternative to surgery for high-risk patients with severe aortic stenosis, but predicting outcomes through frailty measures has shown limited success.
- A study of 171 patients revealed overall quality of life improved post-TAVI, but frailty assessments (10-m walk test and handgrip strength) worsened at 1 month and 1 year.
- Notably, those with the lowest initial frailty levels showed some improvement over time despite the overall trends.
Article Abstract
Background: Transcatheter aortic valve implantation (TAVI) is an effective alternative to surgical valve replacement in high-risk patients with severe aortic stenosis. Although measures of frailty have been used to attempt to predict outcomes in this population, few studies have demonstrated changes in these measures.
Methods: We performed a prospective, observational study of 171 patients undergoing TAVI, of whom 44 had maximal follow-up of 1 month and 50 had maximal follow-up of 1 year. Quality of life was assessed using the Minnesota Living With Heart Failure Questionnaire, Katz Index of Independence in Activities of Daily Living questionnaire, and patient perception of overall well-being. Frailty was measured using the 10-m walk test and handgrip strength testing.
Results: In the overall cohort, participants demonstrated improvements in quality of life metrics, but deterioration in 10-m walk test and handgrip at 1 month. These trends continued at 1 year. However, patients in the lowest quintile of handgrip and 10-m walk test demonstrated a trend of improvements in these metrics during follow-up.
Conclusions: Despite improvements in quality of life after TAVI, no improvements in frailty were observed in patients at 1 year.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242504 | PMC |
| http://dx.doi.org/10.1016/j.cjco.2019.12.006 | DOI Listing |
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