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Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration.
Mol Biol Rep
May 2024
School of Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan, ROC.
Background: The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In contrast, zebrafish display a remarkable capacity for scar-free heart regeneration.
View Article and Find Full Text PDFBasal endothelial glycocalyx's response to shear stress: a review of structure, function, and clinical implications.
Front Cell Dev Biol
March 2024
Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA, United States.
The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the smooth muscle cell interface, are often investigated separately as they are exposed to vastly different stimuli. The apical glycocalyx directly senses fluid shear forces transmitting them intracellularly through connection to the cytoskeleton of the endothelial cell.
View Article and Find Full Text PDFUnravelling the Effects of Syndecan-4 Knockdown on Skeletal Muscle Functions.
Int J Mol Sci
April 2023
Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
The remodelling of the extracellular matrix plays an important role in skeletal muscle development and regeneration. Syndecan-4 is a cell surface proteoglycan crucial for muscle differentiation. Syndecan-4 mice have been reported to be unable to regenerate following muscle damage.
View Article and Find Full Text PDFFingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury.
Intensive Care Med Exp
August 2022
School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Background: Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mechanism for this effect is unknown, and some components of FFP have adverse effects unrelated to the EG. There is some limited evidence that sphingosine-1-phosphate (S1P) within FFP restores the EG by activating the endothelial cell S1P receptor 1 (S1PR).
View Article and Find Full Text PDFSyndecan-4 affects myogenesis via Rac1-mediated actin remodeling and exhibits copy-number amplification and increased expression in human rhabdomyosarcoma tumors.
Cell Mol Life Sci
February 2022
Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.
Skeletal muscle demonstrates a high degree of regenerative capacity repeating the embryonic myogenic program under strict control. Rhabdomyosarcoma is the most common sarcoma in childhood and is characterized by impaired muscle differentiation. In this study, we observed that silencing the expression of syndecan-4, the ubiquitously expressed transmembrane heparan sulfate proteoglycan, significantly enhanced myoblast differentiation, and fusion.
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