AI Article Synopsis
- A 53-year-old woman with rheumatoid arthritis was treated with methotrexate but developed a persistent cough, leading to a lung biopsy that diagnosed her with classic Hodgkin lymphoma.
- After discontinuing methotrexate, she was classified as having methotrexate-associated Hodgkin lymphoma (MTX-HL) due to her treatment history.
- The patient successfully underwent six courses of brentuximab vedotin combined with AVD, achieving a complete metabolic response and remission of her rheumatoid arthritis.
Article Abstract
A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sclerosis classic Hodgkin lymphoma (CHL-NS). She was considered to have "other iatrogenic immunodeficiency-associated lymphoproliferative disorders" (OIIA-LPD), MTX-associated Hodgkin lymphoma (MTX-HL). She received six courses of brentuximab vedotin (BV) in addition to AVD (BV+AVD). A complete metabolic response was obtained, and the RA went into remission. This is the fourth reported case of BV+AVD for MTX-HL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516310 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.4417-20 | DOI Listing |
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