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ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration. | LitMetric

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.

J Mol Cell Cardiol

Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT, USA. Electronic address:

Published: July 2020

AI Article Synopsis

Article Abstract

The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877492PMC
http://dx.doi.org/10.1016/j.yjmcc.2020.05.013DOI Listing

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