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Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL.
Int Immunopharmacol
January 2025
Department of Intensive Care Medicine, The First Hospital of Jilin University, Department of Immunology, College of Basic Medical Sciences. Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. Electronic address:
Objective: To assess the expression levels of autoimmune regulator (Aire) and inducible costimulator molecule ligand (ICOSL), as well as T follicular helper (Tfh) cell numbers in rheumatoid arthritis (RA) patients, and to explore their relationship with RA severity. We also aimed to investigate the effect of Aire on arthritis and its underlying mechanisms.
Methods: The expression levels of Aire, ICOSL, and Tfh cell numbers were measured in RA patients.
Precise Lubrication and Protection of Cartilage Damage by Targeting Hydrogel Microsphere.
Adv Mater
October 2024
Laboratory for Advanced Lubricating Materials, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China.
Osteoarthritis (OA) is a degenerative bone and joint disease characterized by decreased cartilage lubrication, leading to continuous wear and ultimately irreversible damage. This situation is particularly challenging for early-stage OA, as current bio-lubricants lack precise targeting for small inflammatory lesions. In this work, an antibody-mediated targeting hydrogel microspheres (HMS) is developed to precisely lubricate the local injury site of cartilage and prevent the progression of early OA.
View Article and Find Full Text PDFCaspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis.
Int J Oral Sci
August 2024
Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Article Synopsis
- Clinical studies indicate that the bacteria Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is linked to aggressive periodontitis and may worsen rheumatoid arthritis (RA), although the underlying mechanisms remain unclear.
- Research using a mice model showed that systemic infection with A. actinomycetemcomitans leads to arthritis progression through IL-1β secretion and immune cell infiltration, which is tied to the activation of caspase-11 in macrophages.
- The study suggests that blocking this inflammasome activation can reduce arthritis symptoms, providing insight into the relationship between periodontitis infections and RA worsening.
Histological characterization of pulp regeneration using decellularized human dental pulp and mesenchymal stem cells in a feline model.
Tissue Cell
October 2024
Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Regenerative endodontics aims to restore pulp tissues, thus preserving the vitality of the tooth. One promising approach involves the utilization of decellularized human dental pulp (DHDP) as a scaffold repopulated with Wharton's Jelly mesenchymal stem cells (WJMSCs). This study aimed to regenerate pulp tissues using DHDP and WJMSCs following pulpectomy in mature canine teeth of a feline animal model and to investigate the histological features of the regenerated pulp.
View Article and Find Full Text PDFElevated serum levels of anti-collagen type I antibodies in patients with spontaneous cervical artery dissection and ischemic stroke: a prospective multicenter study.
Front Immunol
June 2024
Department of Neurology, University Hospital Leipzig, Leipzig, Germany.
Article Synopsis
- - Researchers investigated the potential link between autoimmunity and spontaneous cervical artery dissection (sCAD) by analyzing anti-collagen type I antibodies in various patient groups, including those with sCAD, ischemic stroke, and healthy controls.
- - A total of 57 sCAD patients were studied alongside control groups, with findings showing that while sCAD patients had higher antibody levels compared to healthy subjects, they had lower levels than those with unrelated ischemic strokes.
- - The study concluded that elevated levels of anti-collagen type I antibodies in sCAD patients are not a direct trigger for the condition but may relate to the metabolism and turnover of collagen type I.
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