AI Article Synopsis
- The study explores the prevalence and significance of joints-muscles-bones (JMBs) involvement in sarcoidosis using F-FDG-PET/CT imaging in 195 patients.
- JMBs were found in 15% of patients, with the axial skeleton being the most affected; patients with bone involvement showed higher rates of hypercalciuria.
- The findings suggest that JMBs involvement is often asymptomatic and coexists with other organ issues, reinforcing the idea that sarcoidosis is a systemic disease rather than a localized one.
Article Abstract
Objectives: In Sarcoidosis joints-muscles-bones (JMBs) localizations are of the least common. F-FDG-PET/CT imaging revolutionized detection of JMBs involvement by adding metabolic activity information and allowing for a comprehensive, whole-body mapping of the disease.
Aim And Methods: This study investigated prevalence, distribution, and clinical significance of JMBs sarcoidosis in 195 consecutive patients that underwent F-FDG PET/CT examination.
Results: Joint and bone involvement were encountered in 15% of patients with a mean of the maximum-standardized-uptake-value (SUV) of 6.1. Most common location was the axial skeleton. Hypercalciuria was significantly more frequent in patients with osseous involvement (p = 0.003). Muscle activity (SUVmax = 2.4) was encountered in 20% of the patients, most frequently in treatment-naïve (p = 0.02). The muscles of the lower extremities were affected the most. Muscle and bone localization coexist in 50% of the cases. JMBs disease was almost asymptomatic, not related to chronicity but to pulmonary, nodal, and systemic disease. Long-term follow-up and treatment response of affected patients confirmed sarcoidosis.
Conclusion: F-FDG-PET/CT revealed JMBs localizations and coexistence with other organ sites supporting the concept that sarcoidosis is a systemic disease. By allowing an integrative interpretation of multi-organ involvement in the context of a pattern highly suggestive of sarcoidosis, it strongly keeps-off the diagnosis of malignancy.
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| http://dx.doi.org/10.1080/17476348.2020.1775587 | DOI Listing |
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