Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398113PMC
http://dx.doi.org/10.1016/j.celrep.2020.107718DOI Listing

Publication Analysis

Top Keywords

allele-specific dna
4
dna methylation
4
methylation interplay
4
interplay repressive
4
repressive histone
4
histone marks
4
marks promoter-mutant
4
promoter-mutant tert
4
tert genes
4
allele-specific
1

Similar Publications

(L.) Sw. is a valuable ornamental plant in the genus , family Orchidaceae, with high economic and ecological significance.

View Article and Find Full Text PDF

Genomic imprinting is the parent-of-origin dependent monoallelic expression of genes often associated with regions of germline-derived DNA methylation that are maintained as differentially methylated regions (gDMRs) in somatic tissues. This form of epigenetic regulation is highly conserved in mammals and is thought to have co-evolved with placentation. Tissue-specific gDMRs have been identified in human placenta, suggesting that species-specific imprinting dependent on unorthodox epigenetic establishment or maintenance may be more widespread than previously anticipated.

View Article and Find Full Text PDF

Background: DNA methylation plays a crucial role in mammalian development. While methylome changes acquired in the parental genomes are believed to be erased by epigenetic reprogramming, accumulating evidence suggests that methylome changes in sperm caused by environmental factors are involved in the disease phenotypes of the offspring. These findings imply that acquired sperm methylome changes are transferred to the embryo after epigenetic reprogramming.

View Article and Find Full Text PDF

Background: The Anopheles culicifacies complex is one of the most important malaria vectors in Southeast Asia and Southeastern Iran. Although the sibling species within this complex are morphologically indistinguishable, they differ significantly in their disease transmission potential, blood-feeding behaviour, and other biological traits. Cytogenetic and chromosomal studies have identified five sibling species within this complex: A, B, C, D, and E.

View Article and Find Full Text PDF

Infertility affects 10-15% of couples worldwide, with male factors accounting for half of cases. Environmental, behavioral, and genetic problems contribute to spermatogenic failure in 30% of idiopathic male infertility cases. Other factors, such as oxidative stress (OS), cause impaired spermatogenesis, abnormal sperm morphology, and reduced motility, eventually triggering male infertility.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!