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Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives. | LitMetric

Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives.

Org Biomol Chem

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China.

Published: May 2020

AI Article Synopsis

Article Abstract

A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.

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Source
http://dx.doi.org/10.1039/d0ob00225aDOI Listing

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