KPC-50 is a KPC-3 variant identified from a clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) an association with a sharp reduction of its carbapenemase activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526841 | PMC |
| http://dx.doi.org/10.1128/AAC.00321-20 | DOI Listing |
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