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| http://dx.doi.org/10.1186/s13054-020-02868-9 | DOI Listing |
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The Diagnosis and Management of Herpes Simplex Pneumonia in the Critical Care Setting: A Comprehensive Review.
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Pulmonary and Critical Care Medicine, Ozarks Medical Center, West Plains, USA.
Herpes simplex virus (HSV) belongs to the family and is divided into two subtypes: HSV-1 and HSV-2. It is known that herpesviruses lie dormant in neural ganglion cells and are reactivated during times of stress, trauma, fever, and immunosuppression. While HSV primarily causes mucosal infections such as cold sores or upper respiratory tract manifestations, it can also lead to serious, life-threatening infections, particularly in immunocompromised patients.
View Article and Find Full Text PDFCharacteristics and prognosis of Herpesviridae-related pneumonia in critically ill burn patients.
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August 2022
AP-HP, GH St-Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, DMU PARABOL, FHU PROMICE, Paris, France; Université de Paris, France; UMR INSERM 942, Institut National de la Santé et de la Recherche Médicale (INSERM), France; F-CRIN INICRCT Network, Nancy, France; Department of Anesthesia and Perioperative Care, University of California, 500 Parnassus Avenue MUE416, Box 0648, San Francisco, CA 94143, USA.
Background: The aim of this study was to describe the prevalence, characteristics and outcome of critically burn patients with pulmonary HSV reactivation.
Methods: Retrospective, single-center cohort study in a burn critical care unit in a tertiary center, including all consecutive severely burn patients with bronchoalveolar lavage performed for pneumoniae suspicion and screened for HSV from January 2013 and April 2017. We used logistic regression to identify factors associated with HSV reactivation and outcomes.
Immortal time bias: a possible explanation for "Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication".
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Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
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